After identifying that antibiotics prevented the formation of polyp, the scientists tried to feed the antibiotic-treated mice stool from their untreated counterparts to examine, if only bacteria may reverse the drug consequences. Once ingesting the gut bacterium from the untreated mice, the once germ-free mice developed polyps.
The researchers additionally transplanted early embryos of the transgenic mice into females of another, cancer-free mouse strain, Swiss Webster. During birth they are inoculated with the bacterium of their surrogate mothers, the mice which are transplanted didn’t develop tumors until they reach twenty five weeks, while the genetically identical controls had tumors by twelve weeks. This showed that little changes within the gut microbiota could have a large influence on tumour growth.
When the scientists examined the bowels of the animal, they identified that bacterium had invaded the connections between the epithelial cells and intestinal epithelial tissue, which is indicated by the cell adhesion molecules presence, as well as weakening of E-cadherin, wherever the polyps had shaped, when compared with adjacent tissue. The researchers additionally discovered an upregulation of inflammatory molecules close to the polyps.
Discuss about the current advancements and research in the “7th European Clinical Microbiology Congress” to be held in London, UK on November 01-03, 2018. Get to know more from our conference website: Clinical Microbiology 2018