Copper plays a key role in angiogenesis and formation of extracellular skin proteins. By introducing copper oxide into wound dressings we allow slow release of copper ions in situ. We demonstrated that application of wound dressings containing copper oxide to wounds inflicted in genetically engineered diabetic mice resulted in increased gene and in-situ upregulation of pro-angiogenic factors (e.g., PLGF, HIF-1a and VEGF), increased blood vessel formation (p<0.05) and enhanced wound closure (p<0.01) as compared to control dressings (without copper) or commercial wound dressings containing silver.
The wound dressings were tested for biocompatibility showing no skin irritation, skin sensitization, pyrogenicity, acute or chronic toxicity in several animal models. In addition, the wound dressing has potent biocidal properties against a wide spectrum of pathogens. The paper will discuss the molecular mechanism by which copper oxide impregnated dressings stimulate wound healing.
Author: Gadi Borkow, MedCu Technologies Ltd. Israel
International Conference on Wound Care, Tissue Repair and Regenerative Medicine
Date & venue: June 14-15, 2018 | London, UK